Research

  

 

 

California Cannabis ~ Clinical Trials

California is home to the most diverse and efficient minds on the planet. Collectively, humans are responsible for all species of life. The Western culture is improving the utilization of our natural resources, as in wind, solar, and desalinization.

We are now seeing a paradigm shift in whole plant food and whole plant medicine, as tax revenue reflects. As we continue to learn and identify more benefits of using botanical plant strains, we improve the human bodies potential to restore it’s energy levels.  https://en.m.wikipedia.org/wiki/Respiration

 

UCSD~ University of California San Diego  

The botanical plant identified by the NIH (National Institution of Health) as Medical Cannabis has made an impression on the brightest minds in medicine at the UCSD (University of California San Diego). There are also clinical trials under the guidance of the NIH on campus at the CMCR (Center for Medical Cannabis Research). These trials are funded by the NIH, a branch of the federal government responsible for reporting on drug abuse in North America. https://en.m.wikipedia.org/wiki/Medical_cannabis

 

 

 

NIH ~ National Institution of Health

 

The National Institution of Health is the government agency responsible for reporting on drug abuse in North America. The NIH has made a paradigm shift on Marijuana, starting with a new name, Medical Cannabis.  Medical cannabis and cannabinoids are recommended by doctors and caregivers for their patients. Some of the typical ailments doctor’s prescribe cannabis for would be: inflammation, anxiety, epilepsy, PTSD, insomnia, cancer. https://www.nih.gov/

 

 

 

CMCR ~ Center for Medical Cannabis Research

Clinical trials are fundamentally validating the therapeutic benefits of medical cannabis. This progress brings the brightest minds together; providing solutions and better treatments for survivors.  It is important to know these clinical trials provide patients access to the whole plant medicine, as an alternative within a treatment plan. To learn more about how CBD may treat your conditions, visit the CMCR.  https://www.cmcr.ucsd.edu/

 

 

Clinical Studies ~ PDR  (Physician Desk Reference)

It is important to know these clinical trials are proving the efficacy of botanical plant medicine, now identified as medical cannabis. This improves the potential of giving patient’s access to the best plant medicine and medical professionals.  Oral Spray is a medical device and it’s 90% absorption may be referenced in the PDF  (Physician Desk Reference). Oral Spray is known for its high absorption rate in clinical trials at the Cancer Research Institute using Medical Cannabis in clinical trials.  https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq

 

 

 

NeuCana ~   Team of Specialists

NeuCana team members use science to support natures ability to heal and restore the human body. As caregivers, NeuCana providers are dedicated to providing to the latest information and research in these clinical trials.  This exposure is the basis for larger scope studies by the NIH on Cannabis and allows NeuCana providers access to the best intelligence pertaining to medical cannabis.  We aim to drive the medicinal aspects of cannabis forward by our team of scientists, organic farmers, and business professionals.

 

 

 

Research with Pregnant Women

“In the near future, larger scope studies and clinical trials may confirm pregnant woman prefer treating with medical cannabis over processing chemicals through an unborn fetus with prescribed pharmaceuticals”. www.NeuCana.com

 

 

 

 

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Here are some published studies on the medicinal benefits of CBD:

Medical Cannabis & General Benefits

 

Anxiety
Bladder
Brain
Breast
Colon
Endocrine
Epilepsy

Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last? – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767492/

Kaposi Sarcoma
Leukemia
Lung
Pain
Prostate
Skin
Sleep

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Additional links found on PubMed:

General

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. (PubMed2008)

Anxiety

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug (PubMed)

Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed)

Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients (PubMed)

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder(PubMed)

Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation (PubMed)

Effects of cannabidiol (CBD) on regional cerebral blood flow (PubMed)

The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors (PubMed)

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system (PubMed)

Plant-based medicines for anxiety disorders, part 2: A review of clinical studies with supporting preclinical evidence (PubMed)

Alzheimer’s

The therapeutic potential of the endocannabinoid system for Alzheimer’s disease(PubMed)

Endocannabinoid signalling in Alzheimer’s disease (PubMed)

A molecular link between the active component of marijuana and Alzheimer’s disease pathology(PubMed)

Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells (PubMed)

The Potential Therapeutic Effects of THC on Alzheimer’s Disease (PubMed)

Cannabinoids for the treatment of dementia (PubMed)

Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression (PubMed)

Cannabidiol: A promising drug for neurodegenerative disorders? (PubMed)

Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer’s disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition(PubMed)

The role of the endocannabinoid system in Alzheimer’s disease: facts and hypotheses (PubMed)

The role of phytochemicals in the treatment and prevention of dementia (PubMed)

Cannabinoids for the treatment of dementia (PubMed)

Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement (PubMed)

Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic (Pub Med)

Can Marijuana Prevent Alzheimer’s? (Next Avenue)

Addiction

Cannabidiol reduces cigarette consumption in tobacco smokers (PubMed)

Cannabidiol inhibits the reward-facilitating effect of morphine (PubMed)

Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances (PubMed)

Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats (PubMed)

Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment(PubMed)

Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents (PubMed)

Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity (PubMed)

Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder (ScienceDirect)

Cannabidiol for the treatment of cannabis withdrawal syndrome (PubMed)

Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study (PubMed)

ADD/ADHD

Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders (Pub Med)

Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats (PubMed)

Subtypes of Attention Deficit — Hyperactivity Disorder (ADHD) and cannabis use (PubMed)

Childhood and current ADHD symptom dimensions are associated with more severe cannabis outcomes in college students (PubMed)

Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: A case report (PubMed)

Fitness to drive in spite (because) of THC (PubMed)

AIDS

Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium (PubMed)

ALS

Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials (PubMed)

Medical Cannabis Helps ALS Patient Outlive her Own Doctor (Jahan Marcu)

Anorexia

Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa(PubMed)

The role of the endocannabinoid system in eating disorders: Neurochemical and behavioural preclinical evidence (PubMed)

Cancer cachexia and cannabinoids (PubMed)

Antibiotic Resistance

Antibacterial cannabinoids from Cannabis sativa: A structure-activity study (PubMed)

Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol (PubMed)

Arthritis

Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis (PubMed)

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis (PubMed)

Involvement of the endocannabinoid system in osteoarthritis pain (PubMed)

The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55 (PubMed)

Atherosclerosis

The role of the endocannabinoid system in atherosclerosis (PubMed)

Cannabinoid receptors in atherosclerosis (PubMed)

The potential use of cannabidiol in the therapy of metabolic syndrome (PubMed)

Asthma

The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke (PubMed)

Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma (PubMed)

Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs (PubMed)

Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways (PubMed)

Bronchodilator effect of delta1-tetrahydrocannabinol (PubMed)

Autism

Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain(Science Daily)

Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders (PubMed)

A novel approach to the symptomatic treatment of autism (Lester Grinspoon M.D., O’Shaughnessy’s)

Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders (PubMed)

Targeting the endocannabinoid system in the treatment of fragile X syndrome (PubMed)

Bipolar

Cannabinoids in bipolar affective disorder: A review and discussion of their therapeutic potential (PubMed)

Cannabidiol was ineffective for manic episode of bipolar affective disorder (PubMed)

Cancer

Cannabidiol as potential anticancer drug (PubMed)

Cannabidiol inhibits angiogenesis by multiple mechanisms (PubMed)

The inhibitory effects of cannabidiol on systemic malignant tumors (PubMed)

Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1 (PubMed)

Marijuana fights cancer and helps manage side effects (Daily Beast)

Endocannabinoids in endocrine and related tumours (PubMed)

A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells (PubMed)

TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer (PubMed)

Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

Cannabis and Cannabinoids (PDQ®)Laboratory/Animal/Preclinical Studies (Natinal Cancer Institute)

Cannabinoids: potential anticancer agents Manuel Guzmán

– Lung Cancer

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C (PubMed)

COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells (PubMed)

Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells (PubMed)

Media ignored expert’s shocking findings that marijuana helps prevent lung cancer(O’Shaughnessy’s)

– Prostate / Colon Cancer

Towards the use of non-psychoactive cannabinoids for prostate cancer (PubMed)

In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines(Scirp.org)

Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent (PubMed)

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer (PubMed)

Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol (PubMed)

– Breast Cancer

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma (PubMed)

Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy (PubMed)

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis (PubMed)

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells(PubMed)

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration (PubMed)

Cannabis and Cannabinoids (PDQ®)Laboratory/Animal/Preclinical Studies (Natinal Cancer Institute)

– Glioblastoma / Brain

Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival (PubMed)

Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines(PubMed)

Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas (PubMed)

Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism (PubMed)

Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target (PubMed)

Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents (PubMed)

Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect (PubMed)

Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme (PubMed)

The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

Leukemia

Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression (PubMed)

Cannabidiol-Induced Apoptosis in Human Leukemia Cells (PubMed)

– Skin Cancer

Anticancer activity of anandamide in human cutaneous melanoma cells (PubMed)

– Kaposi Sarcoma

Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium (PubMed)

– Cancer-related pain

Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain (PubMed)

Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial (PubMed)

Marijuana extract helps prevent chemo pain (UPI)

Scientific Research of CBD

CBD in general

CBD and Alzheimer’s Disease

CBD and Cancer

CBD with Chronic Pain

CBD and Diabetes

CBD and Epilepsy

CBD and Fibromyalgia

CBD and Gastrointestinal Disorders

CBD and HIV


The FDA has prevented any wide scale studies on a whole range of health conditions using Phytocannabinoids for humans or pets. We are not allowed to say or imply that phytocannabinoids have any health benefits. However, the first amendment also protects our rights to tell you about patient experiences, success stories, and the fact that there have been 1480+ international clinical trials regarding the effectiveness of Phytocannabinoids. It is our passion to provide the life-saving effects of phytocannabinoids to our patients.