The Entourage Effect
To explain why whole plant CBD is more effective than pure CBD, the Israeli scientists surmise, “It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD. By other components,” they refer to the approximately 420 additional compounds, including other cannabinoids, terpenes, flavonoids, amino acids, proteins, enzymes, fatty acids, sugars, and so forth. As we discuss in our introductory article about terpenes, these compounds not only give the cannabis plant its scent and flavor, but research has shown that terpenes significantly enhance the therapeutic potential of THC (the most active cannabinoid) while minimizing its psychoactivity. Scientists call this phenomenon in which all the constituents of the cannabis plant work together, “the Entourage Effect.”
CBD Hemp Vs. Whole Plant CBD
A 2015 study by Israeli researchers showed that whole plant CBD-rich cannabis “is superior over [synthetic] CBD for the treatment of inflammatory conditions. ”A review of past research into the anti-inflammatory effects of CBD (one of the two most active cannabinoids or special compounds in cannabis) revealed that administration of pure CBD in these pre-clinical studies resulted in a bell-shaped dose-response curve, meaning that CBD stopped having any therapeutic effect beyond a certain amount. The researchers wondered whether a whole plant CBD-rich extract would respond any differently. They discovered that unlike the bell-shaped dose-response curve of pure CBD, the anti-inflammatory, anti-pain response of whole plant CBD increased with dose, making the whole plant CBD ideal for clinical use.
CMCR Center for Marijuana Research
In 2015, the owner of NeuCana, Tim, confirmed his suspicion about the effects of Cannabis after attended the symposium at University of California San Diego hosted by the National Institution of Health. CMCR is a federally funded research program at UCSD where clinical trials on Medical Cannabis are conducted. This is where a team of scholars, scientist study the effects of Medical Cannabis under the National Institution of Health right here for many years. The research includes pregnant women, seniors, and children. The NIH aims for a larger scope study right here, where a mixed culture of efficient people lives.
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